PREP1: a TALE of transcription factors, EMT and metastasis
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چکیده
review.ifom.eu Epithelial Mesenchymal Transition (EMT) is a reversible process that triggers the loss of epithelial cell features, such as apico-basal polarity and intercellular adhesions, along with the gain of mesenchymal characteristics, including cytoskeletal rearrangements, individual migratory ability and invasiveness. In addition to its roles in embryo development and organ formation, EMT is involved in pathological conditions, such as wound healing, tissue fibrosis and cancer. EMT is controlled by hierarchically organized transcription factors (EMT-TFs) belonging to multiple classes of nuclear proteins, such as Zn finger (SNAIL1, SNAIL2/SLUG, ZEB 1 and ZEB2/ SIP1) and bHLH (TWIST1 and TWIST2) families.
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